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. 2020 Jun 11;33(4):1006–1016. doi: 10.1007/s13577-020-00387-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Vorinostat (SAHA) prevented pancreatic fibrosis in rats of chronic pancreatitis. a Hematoxylin and eosin dyeing of pancreas sections in chronic pancreatitis. b Immunofluorescence staining of GFAP (red, up) or α-SMA (green, down) in pancreatic tissues of rats with chronic pancreatitis after treated with Saline or SAHA (25 mg/kg). c The levels of TNF-α (up) and IL-6 (down) in serums of rats with or without chronic pancreatitis after treated with Saline or SAHA (25 mg/kg). All data are presented as the mean ± S.D. (n = 5). ***P < 0.001, compared with control. Each assay was performed in triplicate