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. 2020 Sep 8;11:621. doi: 10.3389/fendo.2020.00621

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Copyright © 2020 Sun, Jiao, Han, Zhang, Shi, Shi and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mendelian randomization (MR) plots for relationship of epiandrosterone sulfate (EPIA-S) with polycystic ovary syndrome (PCOS). (A) Scatter plot of potential effects of single-nucleotide polymorphisms (SNPs) on EPIA-S vs. PCOS, with the slope of each line corresponding to the estimated MR effect per method. SNPs showing negative signals with EPIA-S are plotted after orientation to the exposure-increasing allele. SNPs with higher effects on both metabolites and PCOS are marked on the plots. (B) Forest plot of individual and combined effects of EPIA-S related SNPs on PCOS. Data are expressed as raw β values with 95% confidence interval (CI).