Table 1.

Sensitivity analysis of causal associations between metabolites and PCOS.

Metabolites	MR-Egger		Weighted median		MR-PRESSO		MR-PRESSO globle test
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	RSS	P-value
Amino acid
Beta-hydroxyisovalerate	4.12 (0.45, 37.68)	0.2096	3.93 (1.14, 13.55)	0.0300	2.84 (1.46, 5.53)	0.0051	15.37	0.9477
Lipid
3-Dehydrocarnitine	17.33 (0.77, 390.47)	0.0727	10.69 (2.44, 46.82)	0.0017	6.72 (2.22, 20.32)	0.0023	34.58	0.2115
Dihomo-linolenate (20:3n3 or n6)	19.51 (0.85, 449.74)	0.0635	3.16 (0.73, 13.57)	0.1223	3.22 (1.25, 8.32)	0.0236	24.31	0.5654
1-Arachidonoylglycerophosphoethanolamine	2.12 (0.05, 94.91)	0.6976	2.02 (0.54, 7.63)	0.2974	2.97 (1.20, 7.36)	0.0259	30.38	0.4551
2-Linoleoylglycerophosphocholine	31.89 (0.97, 1045.31)	0.0518	1.93 (0.50, 7.40)	0.3391	2.71 (1.18, 6.20)	0.0283	17.47	0.7762
Hexanoylcarnitine	3.50 (0.76, 16.1)	0.1076	2.35 (0.92, 6.00)	0.0735	2.65 (1.35, 5.19)	0.0094	24.80	0.4460
Hexadecanedioate	2.81 (1.09, 7.21)	0.0320	1.68 (0.86, 3.28)	0.1272	1.79 (1.11, 2.88)	0.0238	28.95	0.3879
Epiandrosterone sulfate	2.10 (1.18, 3.73)	0.0111	1.84 (1.12, 3.01)	0.0154	1.54 (1.09, 2.19)	0.0290	15.17	0.5190
2-Tetradecenoyl carnitine	0.46 (0.16, 1.33)	0.1498	0.53 (0.25, 1.11)	0.0935	0.52 (0.34, 0.82)	0.0107	13.09	0.8723
7-Alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca)	0.03 (0.01, 3.10)	0.1358	0.21 (0.03, 1.56)	0.1284	0.16 (0.05, 0.58)	0.0133	13.38	0.7102
Nucleotide
N2,N2-Dimethylguanosine	0.20 (0.04, 1.11)	0.0653	0.40 (0.11, 1.50)	0.1751	0.39 (0.18, 0.84)	0.0185	61.28	0.6210
Peptide
Glycylvaline	1.66 (0.11, 26.06)	0.7167	1.98 (0.86, 4.54)	0.1080	2.11 (1.20, 3.70)	0.0407	6.86	0.5691
Xenobiotics
4-Hydroxyhippurate	0.07 (0.01, 5.20)	0.2294	3.76 (1.12, 12.59)	0.0318	2.95 (1.24, 7.05)	0.0351	12.29	0.4479

Significant results for MR estimates (P < 0.05) are shown in bold. PCOS, polycystic ovary syndrome; MR, Mendelian randomization; PRESSO, pleiotropy residual sum and outlier.