Table 2.

Leading SNPs of the identified metabolites and their associations with PCOS.

Metabolites	Leading SNP	Gene	For metabolite			For PCOS
			β	SE	P-value	β	SE	P-value
Amino acid
Beta-hydroxyisovalerate	rs7720978	–	0.030	0.007	7.51E−06	0.061	0.038	0.110
Lipid
3-Dehydrocarnitine	rs6691848	ZMYM6	0.029	0.006	2.12E−06	0.160	0.079	0.042
Dihomo-linolenate (20:3n3 or n6)	rs4978407	PALM2	0.023	0.005	5.90E−06	0.180	0.062	0.004
1-Arachidonoylglycerophosphoethanolamine	rs39741	CACNA2D1	−0.020	0.004	4.51E−06	−0.110	0.056	0.047
2-Linoleoylglycerophosphocholine	rs17160851	PDE1C	0.034	0.007	2.051E−06	0.120	0.083	0.160
Hexanoylcarnitine	rs17304141	SLC44A5	−0.128	0.012	2.46E−26	−0.1100	0.120	0.360
Hexadecanedioate	rs7926241	LOC105376595	0.087	0.019	3.56E−06	0.2700	0.120	0.024
Epiandrosterone sulfate	rs13222543	ZCWPW1	−0.347	0.024	3.31E−47	−0.220	0.100	0.033
2-Tetradecenoyl carnitine	rs6899136	DOCK2	0.035	0.008	7.35E−06	−0.1200	0.053	0.026
7-Alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca)	rs6755317	VWA3B	0.036	0.008	2.03E−06	−0.2100	0.110	0.042
Nucleotide
N2,N2-Dimethylguanosine	rs16986182	DLGAP4	−0.128	0.027	1.81E−06	0.250	0.160	0.120
Peptide
Glycylvaline	rs17093208	OTX2-AS1	−0.067	0.014	3.11E−06	−0.0780	0.048	0.100
Xenobiotics
4-Hydroxyhippurate	rs4587865	LOC105370513	0.043	0.009	1.27E−06	0.0590	0.063	0.350

SNP, single-nucleotide polymorphism; polycystic ovary syndrome.