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. 2020 Sep 8;8:840. doi: 10.3389/fcell.2020.00840

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Copyright © 2020 Wang, Ji, Wang, Qiu, Zhou, Liu, Wan, Lin, Liu, Zhang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-497 overexpression suppresses cell proliferation, migration and colony formation of lung cancer cells. (A) Expression levels of miR-497 was conducted in A549 and H1299 cells. (B) Overexpression of miR-497 decreased cell growth activity. (C) Migration assay of A549 and H1299 cells. The results showed that overexpression of miR-497 inhibited cell migration. (D) Colony formation was conducted in indicated cells, while the activity of colony formation were reduced in miR-497 group compared with miR-NC. Data were presented by mean ± SD. of 3 replicates. *indicated P < 0.05, **indicated P < 0.01.