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. 2020 Sep 8;8:840. doi: 10.3389/fcell.2020.00840

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Copyright © 2020 Wang, Ji, Wang, Qiu, Zhou, Liu, Wan, Lin, Liu, Zhang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of AKT2 reverses the inhibitory effects of miR-497. (A) The expression of AKT2 was rescued by transfection of pCMV-AKT2 for 48 h. (B) Overexpression of miR-497 arrested cell proliferation, but this was rescued upon coexpression of exogenous AKT2 in H1299 cells. (C) MiR-497 overexpression decreased cell migration by its target AKT2 in H1299 cells. (D) Overexpression of AKT2 restored miR-497-inhibited colony formation. Data were presented by mean ± SD of 3 replicates. *or ^# indicated P < 0.05. *indicates significant difference compared to control; ^#indicates significant difference compared to miR-497 treatment plus AKT2.