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. 2020 Sep 8;8:571501. doi: 10.3389/fcell.2020.571501

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Copyright © 2020 Cirino, Aurigemma, Franzese, Lania, Righelli, Ferrentino, Illingworth, Angelini and Baldini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATAC-seq data using P19Cl6 cells differentiated at Day 1. (A) Heat maps of signal distribution around the transcription start site (TSS) ± 10000 bp of 14476 expressed genes in two control (NT, non-targeted siRNA) and two Tbx1^KD (SIT) replicates. (B) Average profiles of enrichment at the TSS in control and Tbx1^KD cells. Note the similar distribution of all four samples. (C) Pie charts illustrate the distribution of ATAC-seq consensus peaks relative to gene features. The distributions are very similar in controls (nt, number of consensus peaks = 23759) and Tbx1^KD cells (siT, number of consensus peaks = 26847).