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. 2020 Sep 8;11:2116. doi: 10.3389/fmicb.2020.02116

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Copyright © 2020 Bhattacharyya, Sinha, Singh, Patel, Ghosh, Sardana, Ghosh and Sengupta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficacy of PGMC in combination with various antifungal agents against Candida albicans. (A) Combination effect of PGMC and antifungal agents against drug-resistant Candida albicans determined using checkerboard assays. (B) In vitro zone of inhibition assays using topical formulations containing no antifungal agent (placebo cream with PGMC), marketed formulation containing 1% clotrimazole and formulation containing 1% clotrimazole plus PGMC against Candida albicans (C) In vitro time kill kinetics of clotrimazole formulation containing PGMC versus marketed formulation of clotrimazole against C. albicans (D) Efficacy of clotrimazole (1%) formulation containing PGMC in a mouse model of cutaneous candidiasis. Fungal load was evaluated at designated time intervals during the efficacy experiment after treatment with antifungal formulations, clotrimazole (1%) topical cream containing PGMC/marketed cream of 1% clotrimazole. The infection control did not receive any treatment. Treatment time points were 24, 36, and 48 h post infection. The data is represented as mean ± SD (n = 4). Statistical analysis was performed using Student’s t-test (^∗∗p < 0.005).