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Dissociation constants (Kd) of interactions between human cGAS and different substrates.
| Substrates | Kd (nM) |
|---|---|
| 145-dsDNA | 350 ± 37 |
| 145-Nucleosome | 67 ± 5 |
| 185-dsDNA | 394 ± 38 |
| 185-Nucleosome | 172 ± 21 |
| 2,450-dsDNA | 68 ± 4 |
| Oligonucleosomes | 66 ± 6 |
| 145-Tailless nucleosome | 79 ± 7 |
