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. 2020 Sep 8;11:2096. doi: 10.3389/fimmu.2020.02096

FIGURE 2.

FIGURE 2

Modulation of cell surface receptor expression by modified vaccinia virus Ankara (MVA) in healthy persons and HIV-ART patients. Whole-blood samples of healthy persons (A) and HIV-ART patients (B) were infected with MVA for 16 h or left non-infected. Cells were stained with a panel of 35 cell markers and analyzed with Tableau and R software as described in the section “Materials and Methods.” The median expression level [median signal intensity (MSI)] of each cell surface receptor of each cell population is illustrated by an individual heatmap. The expression level ranges from dark green (lowest expression) to dark red (highest expression). Significant differences in the level of cell surface receptor expression between non-infected [(A,B) left panel] and MVA-infected [(A,B) middle panel] cell populations are indicated for healthy persons [(A), right table] and HIV-ART patients [(B), right table]. (C) Significant differences in the level of cell surface receptor expression between healthy persons and HIV-ART patients are indicated for non-infected [(C), left table] and MVA-infected [(C), right table] cell populations. Differences with p < 0.05 were considered significant.