TABLE 2.

The characteristics of IDH WT subtype and IDH mutant subtype.

	IDH WT	IDH mutant	References
Corresponds to	Primary GBM	Secondary GBM	Louis et al., 2016
Proportion	90%	∼10%	Louis et al., 2016
Age	Usually > 60	Younger adults	Louis et al., 2016
CpG methylator	Less frequent	More frequent	Brennan et al., 2013
TERT promoter mutation	∼95%	51%	Yan et al., 2009
homologous deletion of CDKN2A/CDKN2B	∼45%	Less	Yan et al., 2009
EGFR alterations	∼41%	0%	Yan et al., 2009
PTEN mutation/deletion	∼25%	0%	Yan et al., 2009
TP53 mutations	∼20%	81%	Yan et al., 2009