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. 2020 Sep 8;14:929. doi: 10.3389/fnins.2020.00929

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Copyright © 2020 Lv, Zhang, Feng, Zhou, Cui, Yang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of opioid receptor antagonists on the antinociception of (pyr)apelin-13. (A,B) The influence of non-selective opioid receptor antagonist naloxone (NLX, 2 mg/kg) on the antinociceptive effect induced by (pyr)apelin-13 (20 mg/kg) in the formalin test. (C,D) The influence of selective KOR antagonist, nor-Binaltorphimine (nor-BNI, 10 mg/kg), on the antinociceptive effect induced by (pyr)apelin-13 in the formalin test. The NLX or nor-BNI was i.v. co-administrated with (pyr)apelin-13, respectively. Values are presented as means ± SEM. n = 7–10/group. **p < 0.01 vs. control; ^#p < 0.05 and ^##p < 0.01 vs. (pyr)apelin-13 treated group.