TABLE 1.

The deacetylase substrates of SIRT2.

Substrates	Site	Mechanism	Functions	References
Par-3 AMPAR α-syn	– K813/819/822/868 K6/10	Active aPKC Degradation Aggregate	Neurogenesis (myelination) Neurogenesis (synaptic plasticity) Neurotoxicity	Beirowski et al. (13) Wang et al. (14) de Oliveira et al. (15)
FOXO1 ACLY PEPCK1	– K540/546/554 K70/71/594	Inhibition Degradate Stability	Metabolism (Adipogenesis) Metabolism (lipogenesis) Metabolism (Gluconeogenesis)	Jing et al. (16) Lin et al. (17) Jiang et al. (18)
CDH1/CDC20 PR-Set7	K69/159, K66 K90	Activate APC/C Chromatin localization	Mitosis regulation Mitosis regulation	Kim et al. (19) Serrano et al. (20)
CDK9 ATRIP	K48 K32	Activate Activate ATR	Genome integrity Genome integrity	Zhang et al. (21) Zhang et al. (22)
PGAM2 G6PD	K100 K403	Activate Activate	Oxidative stress Oxidative stress	Xu et al. (23) Wang et al. (24)
FOXO1	K262/265/274	Unbound to ATG7	Autophagy	Zhao et al. (25)