Table 2.
Plasma concentrations (μg/mL) for meloxicam from seven post-partum cows compared to five mid-lactation cows that received intravenous administration of a single dose of meloxicam at 0.2 mg/kg.
| Time | Mid-lactation (μg/mL) | Post-partum (μg/mL) | P-value |
|---|---|---|---|
| 5 min | 0.96 (0.76–1.18) | 0.88 (0.60–1.32) | 1.00 |
| 10 min | 1.09 (0.68–1.59) | 0.84 (0.69–1.04) | 0.26 |
| 15 min | 0.74 (0.57–0.93) | 0.69 (0.48–1.07) | 0.75 |
| 30 min | 0.57 (0.45–0.71) | 0.64 (0.47–0.92) | 0.14 |
| 60 min | 0.64 (0.48–0.82) | 0.42 (0.27–0.67) | 0.10 |
| 2 h | 0.56 (0.48–0.65) | 0.50 (0.34–0.74) | 1.00 |
| 4 h | 0.45 (0.26–0.69) | 0.46 (0.35–0.61) | 0.87 |
| 8 h | 0.33 (0.27–0.39) | 0.48 (0.36–0.65) | 0.07 |
| 16 h | 0.16 (0.10–0.23) | 0.31 (0.23–0.43) | 0.03 |
| 24 h | 0.09 (0.06–0.12) | 0.20 (0.14–0.28) | 0.01 |
| 48 h | 0.01 (0.008–0.02) | 0.05 (0.009–0.13) | 0.05 |
| 72 h | < LLOQ | 0.03 (0.00–0.12) | – |
| 96 h | < LLOQ | 0.007 (0.005–0.009) | – |
| 120 h | < LLOQ | 0.007* | – |
| 144 h | < LLOQ | < LLOQ | – |
Results are presented as geometric means and 95% confidence interval.
Lower limit of quantification, LLOQ = 0.002 μg/mL. Data was analyzed with the first value below the LLOQ, replaced with LLOQ. The values below this point were discarded and here listed as < LLOQ.
*
No 95% confidence interval display indicates detection limited to one animal.