Table 2.
KEGG immune pathways enriched from unique peptides in SPORE (compared to CON) birds 3 and 7 days post-inoculation.
| KEGG pathway | 3 dpi | 7 dpi | ||
|---|---|---|---|---|
| # Proteins | p-value (FDR) | # Proteins | p-value (FDR) | |
| PI3K-Akt signaling | 56 | 7.73 10−33 | 45 | 1.75 × 10−27 |
| Chemokine signaling | 34 | 3.71 × 10−22 | 29 | 4.11 × 10−20 |
| B cell receptor signaling | 25 | 6.10 × 10−22 | 21 | 2.39 × 10−19 |
| T cell receptor signaling | 26 | 2.70 × 10−20 | 25 | 1.89 × 10−21 |
| Autophagy | 28 | 3.03 × 10−20 | 23 | 2.01 × 10−17 |
| Fc epsilon RI signaling | 22 | 4.95 × 10−19 | 20 | 1.21 × 10−18 |
| Toll-like receptor signaling | 25 | 5.62 × 10−19 | 18 | 1.15 × 10−13 |
| Fc-gamma R-mediated phagocytosis | 22 | 6.25 × 10−17 | 18 | 1.56 × 10−14 |
| Natural killer cell mediated cytotoxicity | 24 | 2.46 × 10−16 | 19 | 2.05 × 10−13 |
| Apoptosis | 23 | 1.09 × 10−14 | 20 | 8.23 × 10−13 |
| TNF signaling | 21 | 1.74 × 10−14 | 22 | 1.70 × 10−17 |
| JAK-STAT signaling | 24 | 3.12 × 10−14 | 21 | 1.51 × 10−13 |
| IL-17 signaling | 18 | 1.28 × 10−12 | 12 | 3.62 × 10−8 |
| Leukocyte transendothelial migration | 19 | 2.61 × 10−12 | 15 | 4.26 × 10−10 |
| Inflammation mediator regulation of TRP channels | 16 | 1.13 × 10−10 | 14 | 3.92 × 10−10 |
| TH17 cell differentiation | NS | 15 | 1.36 × 10−10 | |
| NF-κB signaling | 15 | 1.13 × 10−9 | 15 | 4.30 × 10−10 |
| Wnt signaling | 17 | 4.96 × 10−9 | 13 | 4.14 × 10−7 |
| NOD-like receptor signaling | 17 | 3.69 × 10−8 | 12 | 1.04 × 10−5 |
Proteins statistically significantly differentially phosphorylated uniquely in the distal ileum from the SPORE group were pulled out of the array data and input into STRING for analysis. The top 19 immune pathways from each point are shown in this table. FDR, false-discovery rate.