Table 3.
KEGG metabolic pathways enriched from unique peptides in SPORE (compared to CON) birds 3 and 7 days post-inoculation.
| KEGG pathway | 3 dpi | 7 dpi | ||
|---|---|---|---|---|
| # Proteins | p-value (FDR) | # Proteins | p-value (FDR) | |
| Insulin signaling | 39 | 5.43 × 10−31 | 29 | 3.72 × 10−23 |
| HIF-1 signaling | 31 | 7.33 × 10−26 | 27 | 6.42 × 10−24 |
| AMPK signaling | 30 | 1.42 × 10−22 | 21 | 1.22 × 10−15 |
| Insulin resistance | 28 | 1.25 × 10−21 | 23 | 1.21 × 10−18 |
| mTOR signaling | 31 | 1.78 × 10−21 | 25 | 4.25 × 10−18 |
| Glucagon signaling | 22 | 4.78 × 10−16 | 16 | 1.04 × 10−11 |
| cAMP signaling | 23 | 9.38 × 10−12 | 20 | 3.30 × 10−11 |
| Glycolysis/gluconeogenesis | 14 | 2.66 × 10−10 | 10 | 2.00 × 10−7 |
| cGMP-PKG signaling | 18 | 3.81 × 10−9 | 15 | 3.52 × 10−8 |
| Calcium signaling | 17 | 1.01 × 10−7 | 10 | 0.00041 |
| PPAR signaling | 11 | 3.41 × 10−7 | 9 | 2.88 × 10−6 |
| Propanoate metabolism | 8 | 6.58 × 10−7 | NS | |
| Starch and sucrose metabolism | 8 | 7.88 × 10−7 | 4 | 0.0023 |
| Fatty acid degradation | 8 | 4.91 × 10−6 | 6 | 9.98 × 10−5 |
| Galactose metabolism | 7 | 6.00 × 10−6 | 4 | 0.0019 |
| Fructose and mannose metabolism | 7 | 8.54 × 10−6 | 4 | 0.0023 |
| Carbohydrate absorption and digestion | 7 | 3.30 × 10−5 | 7 | 7.81 × 10−6 |
| Biosynthesis of amino acids | 9 | 1.79 × 10−5 | 7 | 0.00016 |
Proteins statistically significantly differentially phosphorylated uniquely in the distal ileum from the SPORE group were pulled out of the array data and input into STRING for analysis. The top 18 metabolic pathways from each point are shown in this table. FDR, false-discovery rate.