Table 1.
Microbiota changes in gastrointestinal cancer
| First author [Ref.], year | Study group | Samples | Phylum | Genus/species |
|---|---|---|---|---|
| Colorectal cancer | ||||
| Liang [43], 2017 | 203 CRC/236 healthy controls | stool | ↑ Fusobacterium nucleatum | |
| Feng [42], 2015 | 46 CRC/57 healthy controls | stool | ↑ Fusobacterium
↑ Bacteroides ↑ Alistipes ↑ Escherichia ↑ Bilophila ↓ Ruminococcus ↓ Bifidobacterium ↓ Streptococcus |
|
| Ahn [41], 2013 | 47 CRC/94 control subjects | stool | ↑ Bacteroidetes ↓ Firmicutes |
↑ Fusobacterium
↑ Porphyromonas ↑ Atopobium ↑ Porphyromonas |
| Wang [46], 2012 | 46 CRC/56 healthy controls | stool | ↑ Proteobacteria ↓ Bacteroidetes |
↑ Escherichia/Shigella
↑ Streptococcus ↑ Peptostreptococcus ↑ Enterococcus ↓ Bacteroides ↓ Roseburia ↓ Alistipes |
| Gastric cancer | ||||
| Ferreira [62], 2018 | 54 GC/8 chronic gastritis | gastric mucosa biopsy | ↑ Actinobacteria ↑ Firmicutes ↓ Bacteroidetes ↓ Fusobacteria |
↑ Phyllobacterium
↑ Achromobacter ↑ Lactobacillus ↑ Clostridium ↑ Rhodococcus ↓ Helicobacter spp. |
| Coker [65], 2018 | 20 GC/21 superficial gastritis/23 atrophic gastritis/17 IM | gastric mucosa biopsy | ↑ Slackia exigua
↑ Parvimonas micra ↑ Dialister pneumosintes ↑ Prevotella intermedia and oris ↑ F. nucleatum ↑ Catonella morbi |
|
| Wang [63], 2016 | 103 GC/212 chronic gastritis | gastric mucosa biopsy | ↑ Lactobacillus
↑ Escherichia-Shigella ↑ Nitrospirae ↑ Burkholderia fungerum ↑ Lachospiraceae = Helicobacter pylori |
|
| Aviles-Jimenez [61], 2014 | 5 intestinal-type GC/5 non-atrophic gastritis/5 IM | gastric mucosa biopsy | ↑ Lactobacillus
↑ Lachospiraceae ↓ Porphyromonas ↓ Neisseria ↓ Streptococcus sinensis |
|
CRC, colorectal cancer; GC, gastric cancer; IM, intestinal metaplasia.