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. 2020 Mar 17;9(4):426–439. doi: 10.1159/000506352

Fig. 4.

Fig. 4

Infiltration of CD8+ cells in tumors and genetic alterations in oncogenic pathways. a The degree of CD8+ TIMCs and the presence of activating mutations in the β-catenin pathway (path). The median degree of infiltration of CD8+ cells was 6.2 cells/HPF (25–75 percentiles; 1.3–26.4) in tumors with mutation and 17.6 cells/HPF (25–75 percentiles; 5.8–38.0) in tumors without mutation in the β-catenin pathway, respectively (p = 0.0082, Wilcoxon sum-rank test). b The degree of CD8+ TIMCs and the presence of activating mutations in the PI3K-Akt pathway (path) in PD-L1-positive HCCs. The median number of CD8+ cells (25th–75th percentile) was 20.3 (12.5–36.4) in the PD-L1-positive HCCs with mutations in the PI3K-Akt pathway and 94.3 (30.5–119.7) in those without mutations, respectively (p = 0.0332, Wilcoxon sum-rank test).