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. 2020 Sep 11;12(16):1363–1375. doi: 10.2217/epi-2020-0048

Figure 2. . Differentially methylated CpGs and differentially methylated regions in primary biliary cholangitis patients versus controls.

Figure 2. 

(A) Volcano plot for DMCs. The red dots are for those with p-value less than 0.001 (almost all with methylation difference >5%, the green vertical lines). The numbers on the upper corners are hyper- and hypo-methylated DMCs. (B) Significantly enriched KEGG pathways for DMC-associated genes (p < 0.05). (C) DMC distribution by chromosomes. Y axis represents % of CpGs claimed as DMCs relative to total number of CpGs at each chromosome. DMCs on Chr X are overly represented. (D) Enriched KEGG pathways for DMR-associated genes.

DMC: Differentially methylated CpG; DMR: Differentially methylated region; PBC: Primary biliary cholangitis.