Figure 1.

Study area and temporal clustering. A, Monthly distribution of 1332 cases and temporal trend in cases of Kawasaki disease seen at RCHSD between January 2002 and March 2019. B, Time series of daily cases (black dots) and clusters (blue lines), defined as 5 or more cases in 7 days. C, Distribution of case density for the study period; n = 5 is the 97.5th percentile density. D, Monte Carlo simulation drawing 100 time series of 1332 randomly selected dates with the same time trend and seasonality as the true data (blue squares). Comparing that with the true data (black dots) shows more clusters of 6 or 7 cases in the true data than would be expected from a random distribution of established trends and seasonality.