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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Eur J Pharm Sci. 2020 Jul 23;153:105488. doi: 10.1016/j.ejps.2020.105488

Figure 1. Metabolomic analysis of control and ATX-treated mouse urine.

Figure 1.

Wild-type (WT) mice (n = 3) were treated with ATX (12 mg/kg, p.o.). Urine and feces were collected for analysis 18 hours after ATX treatment. (A) Separation of control and ATX-treated mouse urine in OPLS-DA score plots. The t[1] and to[1] values represent the score of each sample in principal component 1 and 2, respectively. (B) Loading S-plot generated by OPLS-DA analysis of urine metabolome of mice treated with ATX. (C) Loading S-plot generated by OPLS-DA analysis of metabolome of ATX in MLM. The X-axis is a measure of the relative abundance of ions and the Y-axis is a measure of the correlation of each ion to the model. These loading plots represent the relationship between variables (ions) in relation to the first and second components present in the OPLS-DA score plot. The top ranking ATX metabolites were labeled in S-plots, respectively. The number of ions (metabolite identification) was accordant with those in Table 1.