Skip to main content
. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Eur J Pharm Sci. 2020 Jul 23;153:105488. doi: 10.1016/j.ejps.2020.105488

Figure 5. Identifying cyclized metabolites (M14 and M15) and detoluene-ATX (M20).

Figure 5.

Incubations without methxoyamine were conducted as described in Fig. 4. All the samples were analyzed using UHPLC-Q Exactive MS. The metabolite elucidation conditions are described in Fig. 4. (A) Chromatograms of metabolite M14 and M15 in HLM. (B) MS/MS of M14. (C) MS/MS of M15. (D) Chromatograms of metabolite M20 in HLM. (E) MS/MS of M20. (F) Formation of detoluene-ATX.