Table 2. Factors Associated With PRS in Boys and Girls in the Study Sample.

Characteristic	PRS
	Low		Moderate		High
	β (95% CI)	P value	β (95% CI)	P value	β (95% CI)	P value
Breast Tanner stage
Threat composite score	0.14 (0.06 to 0.23)	.001	0.05 (−0.01 to 0.11)	.08	0.05 (−0.02 to 0.12)	.19
Deprivation composite score	0.09 (0.01 to 0.16)	.02	0.05 (−0.01 to 0.10)	.10	0.04 (−0.02 to 0.10)	.23
Testicular volume
Threat composite score	0.32 (0.14 to 0.50)	<.001	0.04 (−0.12 to 0.20)	.63	−0.05 (−0.29 to 0.18)	.66
Deprivation composite score	0.41 (0.18 to 0.63)	<.001	0.08 (−0.10 to 0.27)	.38	−0.02 (−0.32 to 0.27)	.88
Pecentage of TL changea
Boys
Threat composite score	1.50 (0.80 to 2.21)	<.001	1.09 (0.43 to 1.75)	.001	0.75 (−0.43 to 1.15)	.13
Deprivation composite score	−0.33 (−1.18 to 0.53)	.45	0.21 (−0.53 to 0.96)	.58	−0.82 (−1.99 to 0.35)	.17
Girls
Threat composite score	2.40 (1.78 to 3.05)	<.001	1.27 (0.77 to 1.77)	<.001	0.32 (−0.10 to 0.74)	.14
Deprivation composite score	0.15 (−0.53 to 0.82)	.67	0.15 (−0.38 to 0.69)	.58	−0.05 (−0.48 to 0.39)	.84
Telomere length at 1-y follow-upa,b
Boys
Threat composite score	−0.02 (−0.03 to −0.01)	<.001	−0.03 (−0.05 to −0.02)	<.001	0.005 (−0.004 to 0.02)	.28
Deprivation composite score	0.002 (−0.01 to 0.01)	.68	−0.01 (−0.02 to 0.003)	.23	−0.003 (−0.01 to 0.01)	.61
Girls
Threat composite score	−0.04 (−0.05 to −0.03)	<.001	−0.02 (−0.03 to −0.01)	<.001	0.001 (−0.006 to 0.008)	.75
Deprivation composite score	−0.001 (−0.01 to 0.01)	.82	−0.003 (−0.01 to 0.003)	.30	0.001 (−0.006 to 0.007)	.94

Abbreviations: PRS, polygenic risk score.

^aAdjusted for age, pubertal status, body mass index, early-life factors (birth weight and gestational age), lifestyle behaviors (physical activity, consumption of sugar-sweetened beverages, and sleep duration), maternal age and body mass index, and deprivation composite score.

^bAdditionally adjusted for telomere length at baseline.