Table 3.
GO terms for PRS via DAVID gene functional classification tool.
| Description | GO term | Gene count | P | Fold enrichment | Adjusted Pa |
|---|---|---|---|---|---|
| Biological process | GO:0035556~intracellular signal transduction | 139 | 3.66E−12 | 1.75 | 2.38E−08 |
| GO:0043547~positive regulation of GTPase activity | 179 | 1.12E−11 | 1.61 | 7.32E−08 | |
| GO:0007165~signal transduction | 316 | 1.85E−10 | 1.38 | 1.20E−06 | |
| GO:0007155~cell adhesion | 146 | 7.70E−10 | 1.61 | 5.02E−06 | |
| GO:0007605~sensory perception of sound | 57 | 2.89E−09 | 2.17 | 1.88E−05 | |
| GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway | 45 | 6.31E−09 | 2.37 | 4.11E−05 | |
| GO:0007411~axon guidance | 61 | 1.02E−07 | 1.94 | 6.67E−04 | |
| GO:0051056~regulation of small GTPase−mediated signal transduction | 53 | 2.55E−07 | 2.00 | 1.66E−03 | |
| GO:0034220~ion transmembrane transport | 73 | 4.88E−07 | 1.76 | 3.18E−03 | |
| GO:0070588~calcium ion transmembrane transport | 47 | 1.40E−06 | 2.00 | 9.05E−03 | |
| Cellular component | GO:0030054~cell junction | 165 | 3.38E−17 | 1.86 | 3.29E−14 |
| GO:0005886~plasma membrane | 958 | 9.87E−13 | 1.20 | 9.60E−10 | |
| GO:0045211~postsynaptic membrane | 85 | 3.98E−12 | 2.08 | 3.88E−09 | |
| GO:0014069~postsynaptic density | 73 | 3.37E−10 | 2.05 | 3.28E−07 | |
| GO:0042383~sarcolemma | 41 | 6.38E−09 | 2.49 | 6.21E−06 | |
| GO:0005938~cell cortex | 52 | 1.28E−08 | 2.19 | 1.25E−05 | |
| GO:0005737~cytoplasm | 1145 | 1.87E−08 | 1.13 | 1.82E−05 | |
| GO:0005829~cytosol | 752 | 7.92E−08 | 1.17 | 7.71E−05 | |
| GO:0005578~proteinaceous extracellular matrix | 89 | 9.45E−08 | 1.72 | 9.19E−05 | |
| GO:0045202~synapse | 65 | 2.78E−07 | 1.86 | 2.70E−04 | |
| GO:0043235~receptor complex | 50 | 3.53E−07 | 2.04 | 3.43E−04 | |
| GO:0043005~neuron projection | 79 | 4.46E−07 | 1.72 | 4.34E−04 | |
| GO:0005911~cell–cell junction | 61 | 1.08E−06 | 1.83 | 1.06E−03 | |
| GO:0005887~integral component of plasma membrane | 343 | 1.79E−06 | 1.25 | 1.74E−03 | |
| GO:0030424~axon | 73 | 2.23E−06 | 1.70 | 2.17E−03 | |
| GO:0043025~neuronal cell body | 96 | 2.30E−06 | 1.58 | 2.24E−03 | |
| GO:0005891~voltage−gated calcium channel complex | 18 | 3.37E−06 | 3.21 | 3.28E−03 | |
| GO:0043197~dendritic spine | 40 | 3.93E−06 | 2.07 | 3.82E−03 | |
| GO:0030018~Z disc | 45 | 3.97E−06 | 1.97 | 3.86E−03 | |
| GO:0016324~apical plasma membrane | 89 | 4.74E−06 | 1.58 | 4.60E−03 | |
| GO:0005856~cytoskeleton | 108 | 5.37E−06 | 1.50 | 5.21E−03 | |
| GO:0030425~dendrite | 99 | 6.85E−06 | 1.53 | 6.65E−03 | |
| GO:0005768~endosome | 72 | 7.71E−06 | 1.65 | 7.47E−03 | |
| Molecular function | GO:0005524~ATP binding | 399 | 8.71E−13 | 1.37 | 1.80E−09 |
| GO:0005509~calcium ion binding | 205 | 1.72E−09 | 1.47 | 3.56E−06 | |
| GO:0005516~calmodulin binding | 73 | 1.73E−09 | 1.99 | 3.57E−06 | |
| GO:0005096~GTPase activator activity | 92 | 1.05E−07 | 1.70 | 2.17E−04 | |
| GO:0003779~actin binding | 91 | 1.80E−07 | 1.68 | 3.72E−04 | |
| GO:0005085~guanyl-nucleotide exchange factor activity | 48 | 2.38E−07 | 2.09 | 4.93E−04 | |
| GO:0005089~rho guanyl-nucleotide exchange factor activity | 34 | 2.14E−06 | 2.27 | 4.42E−03 | |
| GO:0044325~ion channel binding | 44 | 3.20E−06 | 2.00 | 6.59E−03 |
GO Gene ontology.
aBonferroni procedure was applied for an adjusted P.