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. 2020 Sep 15;69(10):2058–2060. doi: 10.2337/dbi20-0031

Figure 1.

Figure 1

Overview of main study findings. In a cross-sectional study within the UK Biobank (n = 431,167), Klimentidis et al. (9) reported that LDLc is inversely associated with T2D prevalence (odds ratio 0.41 [95% CI 0.39, 0.43] per each mmol/L increase in LDLc). Using genetic data from UK Biobank and DIAGRAM (n = 898,130), Klimentidis et al. identified 44 genomic regions, with opposite associations between LDLc and T2D (31 of them then replicated) enriched for genes associated with NAFLD. Their findings suggest that the diabetogenic effect of lipid-lowering medications is in part mediated by increased liver fat content.