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. 2020 May 4;69(10):2094–2111. doi: 10.2337/db19-1057

Figure 2.

Figure 2

Echocardiographic analysis of in vivo cardiac dimensions and function in diabetic mice with short-term overexpression of GLUT4. Representative M-mode images (A) show preserved systolic function following STZ treatment or GLUT4 transgene induction. B: Quantification of ejection fraction from M-mode; additional parameters are reported in Supplementary Table 1. Transmitral Doppler flow reveals diastolic dysfunction in mG4H mice manifested by increased E/A ratio (n = 5–11); representative images (C) and quantification (D). Tissue Doppler imaging also identified an elevated E/E′ ratio in STZ-treated diabetic mice independent of genotype (n = 5–11); representative images (E) and quantification (F). Quantitative data are means ± SEM. *P < 0.05 or **P < 0.01 vs. Con-Veh.