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. 2020 Jul 23;39(18):e104185. doi: 10.15252/embj.2019104185

Figure EV5. Gene expression dysregulation in timeless and ddx11 DT40 cells.

Figure EV5

  1. Dysregulated genes in timeless (left panel), ddx11 (centre panel) and fancj (right panel) mutants relative to wild type. All genes with > 1 transcript per million in both conditions are plotted. Significantly (P ≥ 0.95) upregulated genes shown in red; downregulated in blue.
  2. Venn diagram showing the overlap in genes deregulated in timeless, ddx11 and fancj relative to wild type. P < 2.2 × 10−16 for each pairwise comparison (Fisher hypergeometric distribution).
  3. GC content around the TSS in genes dysregulated in timeless (blue), ddx11 (red) and in both mutants (“overlap”, orange) compared with all genes (black).
  4. Correlation of magnitude and direction of change of genes dysregulated (relative to wild type) in fancj vs. timeless (left panel) and ddx11 (right panel) DT40 cells. r s (Spearman rho) is shown for each correlation.