Table 1.
Distribution of LQTS‐associated genes in this study
| Gene | Total, N = 84 | Unchanged (likely) pathogenic, N = 72 | Reclassified VUS, N = 12 | p‐value a |
|---|---|---|---|---|
| KCNQ1 | 50.0% (42/84) | 54.2% (39/72) | 25% (3/12) | .12 |
| KCNH2 | 36.9% (31/84) | 33.3% (24/72) | 58.3% (7/12) | .12 |
| SCN5A | 9.5% (8/84) | 8.3% (6/72) | 16.7% (2/12) | .32 |
| KCNJ2 | 2.4% (2/84) | 2.8% (2/72) | 0% (0/12) | NA |
| CALM2 | 1.2% (1/84) | 1.4% (1/72) | 0% (0/12) | NA |
Abbreviations: LQTS, long QT syndrome; NA, not available; VUS, variant of unknown significance.
a
Fisher's exact test.