. 2020 Sep 19;23(9):e25610. doi: 10.1002/jia2.25610

Table 3.

The effect of EAAA on retention and viral suppression six months post ART initiation

Population	Control			Intervention			Steptime adjusted		Multivariable adjusted
Population	Number of Failures	Follow‐up time (person‐years)	Rate per person‐year	Number of Failures	Follow‐up time (person‐years)	Rate per person‐year	HR (95%CI) ^a	p‐value ^b	HR (95%CI) ^a	p‐value ^b
Retention
All enrolled participants	316	1665.7	0.19	215	1364.6	0.16	1.60 (1.15 to 2.21)	0.005	1.94 (1.33 to 2.82) ^c	0.0006
SoC‐ineligible	150	851.7	0.18	48	399.6	0.12	1.89 (1.21 to 2.96)	0.005	2.75 (1.69 to 4.50) ^d	<0.0001
SoC‐eligible	138	661.9	0.21	117	839.7	0.14	1.79 (1.20 to 2.66)	0.004	1.84 (1.28 to 2.65) ^c	0.0009
Viral suppression six months post ART initiation
All enrolled participants	352	386.9	0.91	308	691.1	0.45	14.51 (7.31 to 28.79)	<0.0001	22.08 (7.91 to 61.59) ^e	<0.0001
SoC‐ineligible	114	121.9	0.94	65	232.7	0.28	13.79 (6.11 to 31.11)	<0.0001	19.91 (6.14 to 64.61) ^e	<0.0001
SoC‐eligible	225	249.5	0.90	205	428.4	0.48	16.18 (8.31 to 31.51)	<0.0001	30.86 (8.89 to 107.20) ^f	<0.0001
Combined retention and viral suppression
All enrolled participants	723	1649.8	0.44	516	1332.2	0.39	4.88 (2.96 to 8.05)		6.90 (3.11 to 15.31) ^g
SoC‐ineligible	275	847.8	0.32	110	395.2	0.28	4.17 (2.38 to 7.32)		6.22 (2.71 to 14.30) ^c
SoC‐eligible	402	650.0	0.62	308	813.7	0.38	6.51 (4.07 to 10.42)		9.25 (4.53 to 18.91) ^h

^{^a}

HR compared to standard of care rates

^{^b}

Not adjusted for multiplicity

^{^c}

adjusted for steptime, age at study enrolment (18 to <20 years old, 20 to <30 years old, 30 to <40 years old, 40 to <50 years old, 50 to <60 years old, 60+ years old), sex, marital status (married, divorced/widowed, single), education (illiterate/primary, secondary, high school, tertiary), CD4 counts (<350, 350 to 500, >500), WHO stage (stage 1, stage 2, stage 3 or 4), BMI (<18.5, 18.5 to <25, 25 to <30, ≥30), screened for TB symptoms (yes, no), viral load (<5000, 5000 to 30‚000, >30‚000), treatment support (yes, no), level of clinic (Hospital, Clinic with maternity, Clinic without maternity), time from HIV tested positive to enrolment (≤1 year, 1 to ≤3 years, >3 years), clinic volume (Low: < median, High: ≥median

^{^d}

same as footnote 2, plus study enrolment date (continuous)

^{^e}

came as footnote 2, plus study enrolment date (2 knot restricted cubic splines). If CD4/WHO at 180 days post ART initiation was not available, use CD4/WHO at ART initiation if available, or CD4/WHO at study enrolment if available. For WHO stage at 180 days post ART initiation, which had too few missing to use the missing indicator method, the missings were assigned to the reference category.

^{^f}

same as footnote 4

^{^g}

same as footnote 2, plus study enrolment date (2 knots stepwise restricted cubic spline)

^{^h}

same as footnote 2, plus study enrolment date (3 knots stepwise restricted cubic spline).