Table II.
Association between genetic polymorphisms in SFTPC and tuberculosis risk.
| SNP | Variant | Case, n (%) | Control, n (%) | OR (95% CI) | P-valuea | P-valueb | Variant | Case, n (%) | Control, n (%) | P-valuec |
|---|---|---|---|---|---|---|---|---|---|---|
| rs1124 | A | 639 (35.70) | 992 (32.48) | 1.15 (1.02-1.31) | 0.024 | 0.144 | AA | 117 (13.07) | 153 (10.02) | 0.097 |
| G>A | G | 1,151 (64.30) | 2,062 (67.52) | 1 | - | AG | 405 (45.25) | 686 (44.92) | ||
| GG | 373 (41.68) | 688 (45.06) | ||||||||
| rs4715 | A | 548 (30.44) | 886 (29.03) | 1.07 (0.94-1.21) | 0.318 | AA | 82 (9.11) | 118 (7.73) | 0.100 | |
| C>A | C | 1,252 (69.56) | 2,166 (80.97) | 1 | - | AC | 384 (42.67) | 650 (42.60) | ||
| CC | 434 (48.22) | 758 (49.67) | ||||||||
| rs8192309 | A | 268 (14.92) | 472 (15.48) | 0.95 (0.81-1.13) | 0.577 | AA | 21 (2.34) | 40 (2.62) | 0.578 | |
| G>A | G | 1,528 (85.08) | 2,578 (84.52) | 1 | - | AG | 226 (25.17) | 392 (25.71) | ||
| GG | 651 (72.49) | 1,093 (71.67) | ||||||||
| rs8192313 | C | 680 (37.86) | 1,068 (35.02) | 1.13 (1.00-1.28) | 0.045 | 0.270 | CC | 138 (15.37) | 181 (11.87) | 0.050 |
| A>C | A | 1,116 (62.14) | 1,982 (64.98) | 1 | - | CA | 404 (44.99) | 706 (46.30) | ||
| AA | 356 (39.64) | 638 (41.84) | ||||||||
| rs13248346 | A | 406 (22.61) | 639 (20.92) | 1.10 (0.95-1.26) | 0.211 | AA | 50 (5.57) | 62 (4.06) | 0.265 | |
| G>A | G | 1,390 (77.39) | 2,415 (79.08) | 1 | - | AG | 306 (34.08) | 515 (33.73) | ||
| GG | 542 (60.36) | 950 (62.21) | ||||||||
| rs2070686 | A | 453 (25.25) | 799 (26.23) | 0.95 (0.83-1.08) | 0.427 | AA | 54 (6.02) | 109 (7.16) | 0.452 | |
| G>A | G | 1,341 (74.75) | 2,247 (73.77) | 1 | - | AG | 345 (38.46) | 581 (38.15) | ||
| GG | 498 (55.52) | 833 (54.69) |
aP-value was calculated using logistic regression analysis after adjusting for sex and age;
bP-value after Bonferroni correction.
cP-value was calculated by Chi-square test. SNP, single nucleotide polymorphisms; OR, odds ratio; CI, confidence interval.