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. 2020 Aug 4;21(9):e50446. doi: 10.15252/embr.202050446

Figure 4. Protein aggregates accumulate in human metastatic melanoma.

Figure 4

  • A–D
    Immunofluorescence images with Proteostat (red) and DAPI (blue) staining on (A) human normal skin, (B) samples of primitive melanomas, (C) melanoma metastases in brain and (D) melanoma metastases in lung. Scale bar is 30 μm.
  • E
    Details of brain metastases. Scale bar is 30 μm.
  • F
    Quantitation of Proteostat‐positive dots in primitive vs metastatic melanoma tissues: 6 tissues from metastatic lesions and 6 from primitive melanoma lesions were analyzed. For each tissue, two sections were quantified. T‐test analysis was applied. T‐test analysis, **P < 0.01 (N = 6, data are mean ± SEM).