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. 2020 Aug 4;21(9):e50446. doi: 10.15252/embr.202050446

Figure 6. BACE inhibition affects proliferation and chemo‐sensitivity in melanoma cells.

Figure 6

  • A
    MTT assay for IGRs treated with DMSO or NB‐360 (25 μM). N = 4 biological replicates. T‐test analysis **P < 0.01, ***P < 0.001. Data are mean ± SD.
  • B
    MTT assay for IGRs cells treated with DMSO or inhibitor 3I (3 μM). N = 3 biological replicates. T‐test analysis **P < 0.01. Data are mean ± SD.
  • C, D
    MTT assay of IGRs treated with NB‐360 (25 μM) and different concentration of doxorubicin as indicated. N = 4 biological replicates. T‐test analysis: 0.01 < *P < 0.05, **P < 0.01. Data are mean ± SD.
  • E
    T‐test analysis of IC50 values for doxorubicin used alone or in combination with NB‐360 (combo). Data are mean ± SD. T‐test analysis: 0.01 < *P < 0.05; 0.001 < **P < 0.01.