Figure 7. BACE as a new regulator of YAP in metastatic melanoma cells.

In metastatic melanoma, BACE2 activity assists the secretion of protein aggregates into the extracellular space. The presence of these aggregates might be sensed by Agrin, known to activate the YAP signaling cascade, and is able to induce YAP‐mediated CTGF transcription. In turn, melanoma cells treated with BACE inhibitors produce fewer protein aggregates and show a lower YAP transcriptional activity.