Figure 5.

Two binding sites of NF‐κB in the MMP9 proximal promoter mediate its transcriptional regulation. A, Two putative binding sites of NF‐κB are shown in the proximal promoter of MMP9. B, Only the M3 mutant promoter, but neither M1 nor M2, could completely interrupt NF‐κB‐mediated MMP9 transcription. C, Reporter activity of M3 was still significantly decreased after NCOA6 knockdown. All presented results are expressed as the mean ± SD based on at least three independent experiments. **P < .01; the values with different letters are also significantly different (P < .01)