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Summary of Carboxypeptidase E (CPE) Activities Regulating Bone Mass and Energy Balance
| CPE activities | Metabolic and skeletal functions |
|---|---|
| Enzymatic carboxypeptidase activity | Energy balance, negative regulation of obesity and bone marrow adipocyte tissue accumulation |
| Endogenous nonenzymatic activity | Negative regulation of osteoclast differentiation |
| Trophic nonenzymatic activity | Regulation of osteoblast bioenergetics and ERK1/2 signaling |
