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. Author manuscript; available in PMC: 2020 Sep 22.
Published in final edited form as: Immunity. 2019 Apr 16;50(4):924–940. doi: 10.1016/j.immuni.2019.03.024

Figure 4. Immune evasion mediated by TGF-β signaling in late stage cancers.

Figure 4.

The central circle depicts phenotypic transitions instructed by TGF-beta in the distinct immune cell types present in the TME as described in the text. The outer part summarizes the key processes regulated by TGF-beta signaling in immune cells. We depict direct transcriptional responses driven SMADs, in some cases in cooperation with cell specific transcription factors.