Fig. 4.

Multivariate analysis of adiposity (BMI and waist circumference (WC)), markers of insulin sensitivity (HOMA-IR, fasting insulin), plasma adipokines (increased leptin and reduced adiponectin), systemic inflammation (c-reactive protein), sociodemographic factors [age, ethnicity, socioeconomic status (SES), alcohol consumption and smoking status] and DNA methylation of FKBP5 CpG542 and CpG543 in GSAT and ASAT from obese and normal weight women (OPLS-DA, CV-ANOVA: p < 0.0001). Top panels: OPLS-DA cross-validated scores that describe participant variability. Lower panels: the body composition, sociodemographic, insulin sensitivity, inflammation, adipokines and FKBP5 methylation (OPLS weights, w [1] with 95% CI) that discriminate between obese [2] and normal weight [1] women