TABLE 2.
Cross‐sectional Spearman correlations between plasma biomarkers, clinical scales, and age at baseline and 9 and 18 months (A), and cross‐sectional test for conditional independence of clinical scales and one biomarker given the other and age (B)
| A. | ||||||
|---|---|---|---|---|---|---|
| Baseline | 9 months | 18 months | ||||
| NfL (n = 500) | t‐tau (n = 368) | NfL (n = 500) | t‐tau (n = 383) | NfL (n = 500) | t‐tau (n = 382) | |
| Age | 0.432 (P < 0.0001) | 0.128 (P = 0.0143) | 0.390 (P < 0.0001) | 0.138 (P = 0.0068) | 0.368 (P < 0.0001) | 0.064 (P = 0.2111) |
| MMSE | −0.127 (P = 0.0043) | −0.130 (P = 0.0123) | — | — | −0.279 (P < 0.0001) | −0.134 (P = 0.0088) |
| ADAS‐cog | 0.285 (P < 0.0001) | 0.144 (P = 0.0057) | 0.269 (P < 0.0001) | 0.167 (P = 0.0011) | 0.296 (P < 0.0001) | 0.134 (P = 0.0086) |
| CDR‐SB | 0.215 (P < 0.0001) | 0.169 (P = 0.0011) | 0.325 (P < 0.0001) | 0.179 (P = 0.0004) | 0.368 (P < 0.0001) | 0.163 (P = 0.0014) |
| ADL | −0.206 (P < 0.0001) | −0.190 (P = 0.0002) | −0.308 (P < 0.0001) | −0.214 (P < 0.0001) | −0.362 (P < 0.0001) | −0.121 (P = 0.0181) |
| NPI | 0.072 (P = 0.1080) | 0.117 (P = 0.0249) | 0.103 (P = 0.0210) | 0.038 (P = 0.4627) | 0.140 (P = 0.0017) | 0.026 (P = 0.6061) |
| B. | |||
|---|---|---|---|
| Baseline (n = 368) | 9 months (n = 383) | 18 months (n = 382) | |
| Test for conditional independence between clinical scales and NfL given t‐tau and age | P < 0.0001 | P = 0.0004 | P < 0.0001 |
| Test for conditional independence between clinical scales and t‐tau given NfL and age | P = 0.4108 | P = 0.0905 | P = 0.4684 |
MMSE, Mini‐Mental State Examination; ADAS‐cog, Alzheimer Disease Assessment Scale‐Cognitive Subscale; CDR‐SB, Clinical Dementia Rating sum of boxes; ADL, ADCS Activities of Daily Living (ADL); NPI, Neuropsychiatric Inventory.