TABLE 3.

Cross‐sectional test for conditional independence of clinical scales and each biomarker given the other and age

Outcome variable	Conditioned on	NfL at baseline	NfL at 9 months	NfL at 18 months
Change from baseline in ADAS‐cog at 3, 6, 9, 12, 15, and 18 months	ADAS‐cog and age at baseline	P = 0.0023	P = 0.0004	P = 0.0012
Change from baseline in ADAS‐cog at 6, 9, 12, 15, and 18 months	ADAS‐cog and age at baseline and ADAS‐cog change from baseline at 3 months	P = 0.0294	P = 0.0044	P = 0.0075
Change from baseline in ADAS‐cog at 9, 12, 15, and 18 months	ADAS‐cog and age at baseline and ADAS‐cog change from baseline at 3 and 6 months	P = 0.1432	P = 0.0073	P = 0.1088
Change from baseline in ADAS‐cog at 12, 15, and 18 months	ADAS‐cog and age at baseline and ADAS‐cog change from baseline at 3, 6, and 9 months	P = 0.0877	P = 0.0233	P = 0.0313
Change from baseline in ADAS‐cog at 15 and 18 months given	ADAS‐cog and age at baseline and ADAS‐cog change from baseline at 3, 6, 9, and 12 months	P = 0.2365	P = 0.5682	P = 0.0302
Change from baseline in ADAS‐cog at 18 months	ADAS‐cog and age at baseline and ADAS‐cog change from baseline at 3, 6, 9, 12 and 15 months	P = 0.1017	P = 0.9451	P = 0.0073

MMSE, Mini‐Mental State Examination; ADAS‐cog, Alzheimer Disease Assessment Scale‐Cognitive Subscale; CDR‐SB, Clinical Dementia Rating sum of boxes; ADL, ADCS Activities of Daily Living (ADL); NPI, Neuropsychiatric Inventory (NPI).