. 2020 Aug 10;12(9):e12308. doi: 10.15252/emmm.202012308

Table 1.

Baseline sample characteristics

	Controls		AD spectrum		P‐value
	CN Aβ− N = 94	CN Aβ+ N = 55	MCI Aβ+ N = 136	AD dementia N = 15	P‐value
Age	72.9 (5.88)d	72.9 (6.00)d	71.6 (6.54)d	77.9 (7.22)a ^, b ^, c	0.003
Gender (f/m)	41/53	34/21c	56/80b	5/10	0.047
Education	16.9 (2.37)	16.2 (2.67)	16.2 (2.61)	15.5 (2.70)	0.099
ApoE4 (pos/neg)	81/13b ^, c ^, d	30/25a ^, d	51/85a	2/13a ^, b	< 0.001
ADNI‐MEM	1.18 (0.56)c ^, d	1.17 (0.68)c ^, d	0.18 (0.61)a ^, b ^, d	−0.83 (0.33)a ^, b ^, c	< 0.001
MMSE	29.2 (1.07)c ^, d	29.1 (0.88)c ^, d	27.8 (1.81)a ^, b ^, d	22.5 (1.81)a ^, b ^, c	< 0.001
AV45 global SUVR	0.74 (0.03)	0.91 (0.10)	0.97 (0.11)	1.05 (0.07)	< 0.001
Time between AV45 visits	2.16 (0.59)b ^, c ^, d	2.33 (0.85)a ^, c ^, d	2.12 (0.50)a ^, b ^, d	2.00 (0.03)a ^, b ^, c	0.098
CSF sTREM2	4,163 (2,086)	3,701 (2,007)	4,317 (2,212)	4,640 (2,599)	0.270
CSF total tau	220 (78.3)c ^, d	268 (107)c ^, d	333 (132)a ^, b	381 (118)a ^, b	< 0.001
CSF p‐tau₁₈₁	19.3 (7.11)b ^, c ^, d	25.8 (11.4)a ^, c ^, d	32.9 (14.4)a ^, b	39.1 (12.9)a ^, b	< 0.001
Number of participants with tau PETe	14	14	26	0

Sig. (P < 0.05) different from CN AB−.

Sig. (P < 0.05) different from CN AB+.

Sig. (P < 0.05) different from MCI AB+.

Sig. (P < 0.05) different from AD dementia.

Tau PET had to be obtained maximum 3 years after the last joint AV45 PET/CSF sTREM2 assessment.