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. 2020 Sep 6;9(9):e1174. doi: 10.1002/cti2.1174

Figure 2.

Figure 2

Intraarticular injection of lupus serum IgG induces arthritis. (a–d) Representative images of histopathology of knee joints (a, c) and severity of synovitis and bone erosion (b, d) in C57BL/6 mice sacrificed 3 d after intraarticular injection of 20 μL serum from lupus patients, healthy individuals, MRL/lpr mice or C57BL/6 mice. n = 5 per group. These experiments have been repeated at least three times. (e) Severity of arthritis induced by intraarticular injection of lupus serum (20 μL) in TLR4−/− and TLR4+/+ mice. n = 5 per group. (f) Kinetics of arthritis induced by intraarticular injection of lupus serum (20 μL) in C57BL/6 mice. n = 5 per group. (g) Severity of arthritis induced by intraarticular injection of various doses of lupus serum. n = 5 per group. (h) Severity of arthritis in C57BL/6 mice sacrificed 3 d after intraarticular injection of lupus serum with or without IgG depletion (20 μL). n = 5 per group. (i) Histopathology of knee joints in C57BL/6 mice sacrificed 3 d after intraarticular injection of IgG isolated from serum of SLE patients with arthritis (50 μg in 20 μL PBS) and PBS (20 μL). (j) Severity of arthritis in C57BL/6 mice sacrificed 3 d after intraarticular injection of lupus serum IgG (50 μg) and normal serum IgG (50 μg). n = 5 per group. These experiments have been repeated at least three times. *P < 0.05, **P > 0.05.