Figure 5.

The role of FcγRII and FcγRIII in the inhibitory effect of lupus IgG on RANKL‐induced osteoclastogenesis. (a) Number of TRAP‐positive osteoclasts in BMMs from wild‐type and FcγRIIB^−/− mice incubated with RANKL (100 ng) in the absence and the presence of SLE IgG (100 μg). (b) Number of TRAP‐positive osteoclasts in BMMs from wild‐type and FcγRIII^−/− mice incubated with RANKL (100 ng) in the absence and the presence of SLE IgG (100 μg). These experiments have been repeated at least three times. Data are represented as mean ± SEM. Group with RANKL compared with group with RANKL + SLE IgG, *P < 0.05.