TABLE 4.
Multivariate regression of significant demographic, inflammatory markers, and physiologic related to behavioral symptoms as measured using the HAMD, HAM‐A, and MMSE
| Variable | Regression coefficient | t | p |
|---|---|---|---|
| Depression (HAMD) | |||
| IFN‐γ | .06 | 3.30 | .00** |
| CRP | .18 | 1.57 | .12 |
| Marriage status | −.29 | −2.65 | .01 |
| Anxiety (HAMA) | |||
| IL‐2 | −.02 | −3.25 | .00** |
| IL‐1α | .15 | 1.32 | .19 |
| GDNF | .08 | 0.61 | .54 |
| IFNγ | .11 | 0.94 | .35 |
| KPS | .24 | 2.20 | .03 |
| Cognitive function (MMSE) | |||
| TNF‐α | −.20 | −1.04 | .30 |
| GDNF | −.14 | −1.21 | .23 |
| IL−2 | .03 | 5.80 | .00** |
| IL−8 | −.06 | −0.54 | .59 |
| CRP | −.10 | −0.40 | .69 |
F (depression) = 10.88, p = .00, adjusted R 2 = .12; F (anxiety) = 10.53, p = .00, adjusted R 2 = .12; F (cognitive function) = 33.60, p = .00, adjusted R 2 = .32.
**difference is highly statistically significant.