Table 1.

Results of a systematic review of hydrocortisone and fludrocortisone for septic shock, according to control group

Outcome		Risk ratio (95% confidential interval)
		Overall	Versus corticosteroid‐free	Versus hydrocortisone only
Mortality	28‐day mortality	0.88 (0.78–0.99)	0.88 (0.78–0.99)	N/A
	In‐hospital mortality	0.89 (0.81–0.97)	0.88 (0.80–0.98)	0.91 (0.75–1.11)
	Long‐term mortality	0.90 (0.83–0.98)	0.89 (0.81–0.97)	0.94 (0.78–1.13)
Shock reversal	Vasopressor withdrawal at day 28	1.06 (1.01–1.12)	1.06 (1.01–1.12)	N/A
	Vasopressor‐free days up to day 28 (days)	2.0 (0.8–3.2) †	2.0 (0.8–3.2) †	N/A
Adverse events	Superinfection	1.14 (0.85–1.51)	1.08 (0.86–1.35)	1.54 (1.05–2.26)
	GI bleeding	0.96 (0.66–1.39)	0.96 (0.66–1.39)	N/A
	Hyperglycemia	1.07 (1.03–1.12)	1.07 (1.03–1.12)	N/A
	Psychiatric disorders	0.33 (0.01–8.06)	0.33 (0.01–8.06)	N/A

Bold values indicate significant difference.

GI, gastrointestinal; N/A, not applicable.

^†Vasopressor‐free days were presented as mean difference.