Figure 1.

Schematic representation of the genomic structure of human WDR62, CDK5RAP2, ASPM, CENPJ, and STIL along with the causal variants. Figure shows all the known and novel mutations of WDR62, CDK5RAP2, ASPM, CENPJ, STIL, and CEP135 causing primary and syndromic microcephaly due to the mutations in the respective genes. Exons are drawn according to the given scale whereas introns are shown as arbitrary lines. White boxes denote untranslated regions. Notice that asterisk (*) represents the novel mutations found in this study. ASPM variant;c.3384dupT, previously known as c.3384_3385insT, is renamed according to the HGVS (Human Genome Variation Society) guidelines