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Depiction of potential humoral mechanisms that may contribute to SnPP‐mediated cytoresistance. In addition to activating the Nrf2 pathway (denoted by asterisks) SnPP activates IL‐10 in spleen and IL‐6/TGF beta 1 in liver (as assessed by their mRNAs). Elevations in their plasma concentrations leads to renal filtration and “organ cross talk”. This allows for these cytoprotective cytokines to contribute to Nrf2’s cytoprotective activities
