TABLE 2.

Mouse renal cortical mRNA levels 4 hr following SnPP or vehicle administration

Analyte mRNA	Vehicle	SnPP (4 hr)	p value
HO−1	0.05 ± 0.0	1.42 ± 0.38	<0.0001
HSP−70	1.64 ± 0.47	1.90 ± 0.74	NS
IL−10	0.49 ± 0.14	0.72 ± 0.24	NS
IL−6	0.28 ± 0.12	0.32 ± 0.13	NS
TNF‐α	0.12 ± 0.02	0.15 ± 0.05	NS
MCP−1	0.64 ± 0.07	0.60 ± 0.05	NS
TGFβ1	0.62 ± 0.02	0.58 ± 0.04	NS

Results are presented as ratios to simultaneously determined GAPDH product. SnPP activity was confirm by a 25‐fold increase in HO‐1 mRNA. This was not due to a non‐specific heat shock protein response, given the lack of increase in HSP70 mRNA. SnPP did not activate any of the five tested cytokine/chemokine genes. Values are means (±1 SEM).