TABLE 3.
Mouse spleen mRNA levels 4 hr following SnPP or vehicle injection
| Analyte mRNA | Vehicle | SnPP (4 hr) | p value |
|---|---|---|---|
| HO−1 | 1.1 ± 0.1 | 1.8 ± 0.1 | <0.005 |
| HSP−70 | 2.4 ± 0.4 | 2.0 ± 0.3 | NS |
| IL−10 | 0.70 ± 0.10 | 1.62 ± 0.3 | <0.015 |
| IL−6 | 1.0 ± 0.2 | 1.3 ± 0.3 | NS |
| TGFβ1 | 2.4 ± 0.2 | 2.3 ± 0.2 | NS |
SnPP activated the HO‐1, but not the HP70 gene. It also caused 2.3‐fold increase in IL‐10 mRNA. However, the remaining cytokine mRNAs remained at control levels. Values are means (±1 SEM). Results are presented as ratios to simultaneously determined GAPDH product.