TABLE 4.
Mouse liver mRNA levels 4 hr following SnPP or vehicle injection
| Analyte mRNA | Vehicle | SnPP (4 hr) | p value |
|---|---|---|---|
| HO−1 | 0.13 (0.01) | 0.61 (0.06) | <0.0001 |
| HSP−70 | 0.75 (0.1) | 0.95 (0.1) | NS |
| IL−10 | 0.52 (0.14) | 0.65 (0.12) | NS |
| TGFβ1 | 2.4 (0.1) | 3.0 (0.2) | <0.035 |
| IL−6 | 0.3 (0.1) | 1.1 (0.1) | <0.001 |
SnPP activated the HO‐1, but not the HSP‐70 gene. It also caused a near fourfold increase in IL‐6 mRNA. A modest, but significant, increase in TGFβ1 mRNA was also observed. Values are means (± 1 SEM). Results are presented as ratios to simultaneously determined GAPDH product.