Table C.3.
Selected TK parameters for PFASs other than PFOS and PFOA in animals
| PFAS | Species (sex) | Route(j) | Dose (μmol/kg) | Half‐life | Clearancetot (mL/kg per day) | Volume of distribution (mL/kg) | Reference |
|---|---|---|---|---|---|---|---|
| PFBA |
Rat (F) Rat (M) Rat (F) Rat (M) Mice (F) Mice (M) Mice (F) Mice (M) Monkey (F) Monkey (M) |
i.v. i.v. G G G G G G i.v. i.v. |
140 140 140 140 140 140 47 47 47 47 |
1.03 ± 0.03 h 6.4 ± 0.54 h 1.8 ± 0.3 h 9.2 ± 0.8 h 3.1 ± 0.3 h 16.3 ± 7.2 h 2.9 ± 0.3 h 13.3 ± 4.6 h 41.0 ± 4.7 h 40.3 ± 2.4 h |
3,318 ± 66(a) 766 ± 55(b) 1,718 ± 163(a) 444 ± 27(b) 835 ± 38(c) 254 ± 549(d) 730 ± 29(c) 240 ± 63(d) 1,792 ± 152(e) 1,694 ± 209(f) |
187 ± 3 253 ± 6 173 ± 21 209 ± 10 134 296 107 152 443 ± 59 526 ± 68 |
Chang et al. (2008) Chang et al. (2008) Chang et al. (2008) Chang et al. (2008) Chang et al. (2008) Chang et al. (2008) Chang et al. (2008) Chang et al. (2008) Chang et al. (2008) Chang et al. (2008) |
| PFHxA |
Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (M) Monkey (F) Monkey (M) |
i.v. i.v. G G G (25 d) G (25 d) G i.v. i.v. |
31.8 31.8 159.2 159.2 159.2 159.2 0.32 31.8 31.8 |
0.4 h 1.0 h 2.6 h 2.2 h 2.7 h 2.2 h 2.9 (2.1‐4.3) h 2.4 ± 1.7 h 5.3 ± 2.5 h |
18,600 2,784 NR NR – – NR 3,264 ± 528 2,928 ± 576 |
466 175 NR NR – – 760 474 ± 349 989 ± 579 |
Chengelis et al. (2009) Chengelis et al. (2009) Chengelis et al. (2009) Chengelis et al. (2009) Chengelis et al. (2009) Chengelis et al. (2009) Iwabuchi et al. (2017) Chengelis et al. (2009) Chengelis et al. (2009) |
| PFHpA |
Rat (F) Rat (M) Mice (F) Mice (M) Mice (F) Mice (M) |
i.v. i.v. i.v. i.v. G G |
48.6 48.6 0.31 0.31 3.13 3.13 |
0.05 ± 0.01 d 0.10 ± 0.05 d NR NR NR NR |
3,070 ± 781 1,604 ± 558 257 ± 124 347 ± 86 190 ± 22 293 ± 154 |
201 ± 29 196 ± 19 80 ± 20 70 ± 10 NR NR |
Ohmori et al. (2003) Ohmori et al. (2003) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) |
| PFNA |
Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Mice (F) Mice (M) Mice (F) Mice (M) Mice (F) Mice (M) Mice (F) Mice (M) |
i.v. i.v. G G G G G G G i.v. i.v. G G G G G G i.v. i.v. i.v. G |
48.6 48.6 2.16 2.16 6.47 6.47 21.6 21.6 0.11 6.47 6.47 6.47 6.47 2.16 2.16 21.6 21.6 0.31 0.31 3.13 3.13 |
2.44 ± 0.41 d 29.6 ± 2.3 d NR 42.1(33‐56) d 32.0(3‐119) d 23.6(20‐28) d NR 28.0(25‐32) d 29(18‐64) d 4.4 ± 0.2 d 40.2 ± 18.7 d 6.4 ± 1.1 d 54.6 ± 2.5 25.7(23‐29) d 34.4(29‐41) d 68.8(42‐120) d 228(70‐796) d NR NR NR NR |
106 ± 31 6.9 ± 0.6 NR NR NR NR NR NR NR 16.6 ± 1.3 7.4 ± 1.4 NR NR NR NR NR NR 5.1 ± 2.3 3.9 ± 1.9 2.4 ± 1.0 4.0 ± 1.7 |
243 ± 49 287 ± 13 125(86‐164) 113(67‐158) 171(104‐238) 139(82‐196) 146(90‐201) 110(65‐154) 880 45.9 ± 3.7 363 ± 183 NR NR 192(165‐220) 328(0‐1060) 192(165‐220) 328(0‐1060) 150 ± 40 220 ± 60 NR NR |
Ohmori et al. (2003) Ohmori et al. (2003) Tatum‐Gibbs et al. (2011) Tatum‐Gibbs et al. (2011) Tatum‐Gibbs et al. (2011) Tatum‐Gibbs et al. (2011) Tatum‐Gibbs et al. (2011) Tatum‐Gibbs et al. (2011) Iwabuchi et al. (2017) Kim et al. (2019) Kim et al. (2019) Kim et al. (2019) Kim et al. (2019) Tatum‐Gibbs et al. (2011) Tatum‐Gibbs et al. (2011) Tatum‐Gibbs et al. (2011) Tatum‐Gibbs et al. (2011) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) |
| PFDA |
Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Mice (F) Mice (M) Mice (F) Mice (M) |
i.v. i.v. i.v. i.v. G G i.v. i.v. G G |
48.6 48.6 1.95 1.95 1.95 1.95 0.31 0.31 3.13 3.13 |
58.6 ± 5.8 d 39.9 ± 8.6 d 50.0 ± 2.3 d 109.4 ± 18.7 d 74.6 ± 10.2 d 80.0 ± 5.5 d NR NR NR NR |
5.3 ± 0.2 5.2 ± 1.3 0.8 ± 0.1 0.8 ± 0.1 NR NR 2.8 ± 1.2 2.2 ± 0.9 2.2 ± 1.1 3.9 ± 1.8 |
441 ± 55 348 ± 15 58.4 ± 4.5 118.2 ± 9.3 NR NR 200 ± 50 250 ± 60 NR NR |
Ohmori et al. (2003) Ohmori et al. (2003) Kim et al. (2019) Kim et al. (2019) Kim et al. (2019) Kim et al. (2019) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) |
| PFUnDA |
Mice (F) Mice (M) Mice (F) Mice (M) |
i.v. i.v. G G |
0.31 0.31 3.13 3.13 |
NR NR NR NR |
3.4 ± 1.5 2.8 ± 1.0 3.1C1.7 5.7 ± 2.6 |
280 ± 80 33 ± 60 NR NR |
Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) |
| PFDoDA |
Mice (F) Mice (M) Mice (F) Mice (M) |
i.v. i.v. G G |
0.31 0.31 3.13 3.13 |
NR NR NR NR |
4.8 ± 2.4 4.4 ± 1.6 5.2 ± 3.2 9.4 ± 4.1 |
350 ± 100 570 ± 210 NR NR |
Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) |
| PFTrDA |
Mice (F) Mice (M) Mice (F) Mice (M) |
i.v. i.v. G G |
0.31 0.31 3.13 3.13 |
NR NR NR NR |
7.2 ± 3.2 6.8 ± 2.5 17.1 ± 12.0 34.2 ± 16.6 |
430 ± 140 580 ± 200 NR NR |
Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) |
| PFTeDA |
Mice (F) Mice (M) Mice (F) Mice (M) |
i.v. i.v. G G |
0.31 0.31 3.13 3.13 |
NR NR NR NR |
10.4 ± 6.0 10.4 ± 4.6 48.7 ± 381 106.3 ± 46.6 |
430 ± 130 550 ± 180 NR NR |
Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) Fujii et al. (2015) |
| PFBS |
Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Monkey (F) Monkey (M) Monkey (F) Monkey (M) |
i.v. i.v. i.v. i.v. G G i.v. i.v. G G G G G G i.v. i.v. i.v. i.v. |
33.3 33.3 100 100 100 100 11.8 11.8 11.8 11.8 59.1 59.1 295.7 295.7 33.3 33.3 33.3 33.3 |
0.6 h 2.1 h 4.0 ± 0.2 h 4.5 ± 2.2 h 7.4 ± 0.8 h 4.7 ± 0.4 h 0.36 ± 0.03 h(k) 2.26 ± 0.3 h(k) 1.5 ± 0.1 h(k) 4.4 ± 18.1 h(k) 1.2 ± 0.1 h(k) 2.7 ± 0.8 h(k) 1.1 ± 0.1 h(k) 2.86 ± 0.4 h(k) 11.3 ± 2.5 h 83.2 ± 41.9 h(g) 13.2 ± 2.9 h 95.2 ± 27.1 h(g) 8.1 ± 2.0 h 15 ± 9.4 h |
7,464 946 56,280 ± 4,800(a) 11,424 ± 3,264(b) NR NR 6,048 ± 432 8,028 ± 48 3,648 ± 480 624 ± 60 4,392 ± 936 902 ± 74 6,216 ± 792 1,812 ± 139 8,832 ± 2,880(h) 12,264 ± 3,384 552 ± 240 298 ± 158 |
288 118 351 ± 34 330 ± 32 391 ± 105 676 ± 55 123 ± 12(l) 113 ± 16(l) 328 ± 57(l) 164 ± 677(l) 326 ± 95(l) 148 ± 52(l) 415 ± 83(l) 311 ± 55(l) 255 ± 17 254 ± 31 248 ± 45 209 ± 29 |
Chengelis et al. (2009) Chengelis et al. (2009) Olsen et al. (2009) Olsen et al. (2009) Olsen et al. (2009) Olsen et al. (2009) Huang et al. (2019a) Huang et al. (2019a) Huang et al (2019a) Huang et al (2019a) Huang et al (2019a) Huang et al (2019a) Huang et al (2019a) Huang et al (2019a) Olsen et al. (2009) Olsen et al. (2009) Chengelis et al. (2009) Chengelis et al. (2009) |
| PFHxS |
Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Rat (F) Rat (M) Mice (F) Mice (M) Mice (F) Mice (M) Monkey (F) Monkey (M) |
i.v. i.v. G G i.v. i.v. i.v. i.v. G G i.v. i.v. i.v. G G i.v i.v. G G G G G G G G G G i.v. i.v. |
22.8 22.8 22.8 22.8 22.8 22.8 10 10 10 10 10 25 25 10 25 9.1 9.1 9.1 9.1 36.5 36.5 73 73 2.3 2.3 45.7 45.7 22.8 22.8 |
1.83 ± 0.26 d 6.83 d 0.83 ± 0.53 d NR 1.64 ± 0.08 d 29.1 ± 0.6 d 0.88 ± 0.07 d(i) 20.7 ± 4.0 d(i) 1.72 ± 0.11 d(i) 26.9 ± 0.4 d(i) 1.61 ± 0.06 d 2.03 ± 0.09 d 34.1 ± 0.88 d 1.69 ± 0.06 d 34.1 ± 4.85 d 0.7 ± 0.08 d(k) 13.0 ± 1.5 d(k) 2.33 ± 0.07 d(k) 17.6 ± 1.8 d(k) 2.19 ± 0.06 d(k) 16.5 ± 1.1 d(k) 1.98 ± 0.05 d(k) 14.8 ± 1.2 d(k) 24.8 d 30.5 d 26.8 d 28.0 d 87 ± 27 d 141 ± 30 d |
119 ± 47 40.32 NR NR 53.35 ± 4.38 6.75 ± 0.06 227.9 ± 6.7(i) 9.0 ± 0.05(i) 124.8 ± 3.4(i) 7.2 ± 0.06(i) 56.2 ± 6.2 52.6 ± 8.6 6.4 ± 0.06 65.3 ± 8.2 6.6 ± 1.2 65.5 ± 3.1 4.7 ± 0.5 46.1 ± 2.2 4.8 ± 0.4 59.0 ± 3.6 5.7 ± 0.3 96.2 ± 5.8 9.0 ± 0.6 2.7 2.9 3.8 4.8 1.9 ± 0.4 1.3 ± 0.1 |
278 ± 66 NR NR NR 126 ± 14 275 ± 5 289.3 ± 23.8(i) 268.9 ± 52.1(i) 255.9 ± 18.2(i) 277.6 ± 3.9(i) 130.4 ± 5.5 153.9 ± 20.2 314.8 ± 23.2 158.6 ± 7.8 326.7 ± 20.0 66.3 ± 7.6(l) 123 ± 11(l) 155 ± 9(l) 123 ± 11(l) 186 ± 14(l) 137 ± 9(l) 264 ± 20(l) 192 ± 17(l) 96 129 147 195 213 ± 28 287 ± 52 |
Sundström et al. (2012) Sundström et al. (2012) Sundström et al. (2012) Sundström et al. (2012) Sundström et al. (2012) Sundström et al. (2012) Kim et al. (2016a) Kim et al. (2016a) Kim et al. (2016a) Kim et al. (2016a) Kim et al. (2018) Kim et al. (2018) Kim et al. (2018) Kim et al. (2018) Kim et al. (2018) Huang et al. (2019a) Huang et al. (2019) Huang et al. (2019) Huang et al. (2019a) Huang et al. (2019a) Huang et al. (2019a) Huang et al. (2019a) Huang et al. (2019a) Sundström et al. (2012) Sundström et al. (2012) Sundström et al. (2012) Sundström et al. (2012) Sundström et al. (2012) Sundström et al. (2012) |
d: day; F: female; M: male; G: gavage; i.v.: intravenous; m: month; PFAS: perfluoroalkyl substance; PFOS: perfluoroheptane sulfonate; PFOA: perfluorooctanoic acid; TK toxicokinetic; y: years; NR: Not Reported.
Unless otherwise specified, values are means ± SD or means and range.
(a): Based on an average weight of 200 g.
(b): Based on an average weight of 250 g.
(c): Based on an average weight of 25 g.
(d): Based on an average weight of 35 g.
(e): Based on an average weight of 3 kg.
(f): Based on an average weight of 7 kg.
(g): Calculated from γ phase of elimination profile.
Expressed as ml/d (weight of the animals not reported).
Values reported as mean ± SEM.
Unless otherwise stated, single dose exposure is given.
Elimination half‐life based on k10 calculation.
Volume of distribution for the central compartment.